Category Archives: Medical

The Wisdom of Crowds

How the Internet saved my life and can save yours from The Anointed (medical experts and government dietary guidelines)


Root Cause Analysis

Ivor Cummins is obviously a gifted Chemical Engineer from Dublin, Ireland. He has posted videos of two brilliant seminars that he presented to his colleagues in 2014 regarding his biochemical engineering root cause analysis of cholesterol and inflammatory disease.

His Bio

I completed a Chemical Engineering degree originally and have subsequently spent 25 years primarily in Engineering Lead and Engineering Manager positions. I have worked in the Medical Device, Special Purpose Equipment and Electronic Component industries, always gravitating towards the most complex interactions where the Physics comes alive. My specialty throughout has been leadership in Complex Problem Solving Methodology (Comparative Analysis, Mechanistic Analysis and Experimental/Statistical Inference) – the ultimate destination was always Root Cause Resolution in the minimum timeframe.

Following less-than-ideal blood test results mid last year, I went back to my Biochemical Engineering roots and intensively studied the mechanistic physics and primary drivers of Dyslipidemia, elevated GGT and Serum Ferritin; as the journey became a fixation I also analysed several hundred related papers and studies carried out over the past 5 decades, and a few prior to this period. I found the value of the technical expertise gained during my career to be of paramount, indeed crucial importance in this odyssey. I thus realized that to be successful in determining root cause and solution in this complex arena, required far more than a general medical background.

His Seminars

  1. The Root Cause of Appetite Dysfunction, Obesity, Diabetes and Inflammatory Disease
  2. The Cholesterol Conundrum – and Root Cause Solution

These seminars are long, but some of the most informative ones you will find on these topics….again, two brilliant seminars!  You will learn much.

His Website

The Fat Emperor

http://www.thefatemperor.com


It’s About Time!

In 1961 and 1984 Time magazine published cover stories citing that dietary saturated fat and cholesterol was the cause of heart disease:

Diet & Health – Ancel Keyes…January 13, 1961
Ancel Keyes fabricated data and publish his famous Seven Countries Study.  This bad science earned him a place on the cover of  Time magazine.

Cholesterol. And Now the Bad NewsMarch 26,1984
By the end of the 1980’s there were widespread academic statements that the Lipid Hypothesis was proven beyond reasonable doubt.

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Here is the June 12, 2014 cover story that finally points to the truth!

Ending The War on Fat
“Don’t Blame Fat. For decades, it has been the most vilified nutrient in the American diet. But new science reveals fat isn’t what’s hurting our health.”

Video: The Truth About Fat.  Though not really the truth, this video points people in the right direction.

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Annals of Internal Medicine – 18 March 2014
Association of Dietary, Circulating, and Supplement Fatty Acids With Coronary Risk: A Systematic Review and Meta-analysis

Conclusion: Current evidence does not clearly support cardiovascular guidelines that encourage high consumption of polyunsaturated fatty acids and low consumption of total saturated fats.


Uh-Oh Cipro!

I almost fell out of my chair upon hearing about the popular antibiotic Cipro at about 36 minutes into this podcast:

http://www.bulletproofexec.com/124-resistant-starch-revealed-with-richard-nikoley-and-tim-steele-podcast

Two years ago I was prescribed Cipro on two occasions about three months apart.  I took 14-day treatments for diverticulitis.  It was shortly thereafter that I began to experience Parkinson’s symptoms on the right-side of my body.  Could Cipro have been the trigger or even the sole cause of my neurological issues?  I will never be able to prove this, but I now have reason to believe that this was a likely cause.  Check out the following links.  It is unbelievable that this poison is still available and that so many doctors prescribe it.

The FDA has since black boxed Cipro for knowing to cause among other things, permanent nerve damage!

http://www.fda.gov/Drugs/DrugSafety/ucm365050.htm

The U.S. Food and Drug Administration (FDA) has required the drug labels and Medication Guides for all fluoroquinolone antibacterial drugs be updated to better describe the serious side effect of peripheral neuropathy. This serious nerve damage potentially caused by fluoroquinolones may occur soon after these drugs are taken and may be permanent.

Here is a NY Times Article:

http://well.blogs.nytimes.com/2012/09/10/popular-antibiotics-may-carry-serious-side-effects

Here is the most complete website on the topic called Floxie Hope:

http://floxiehope.com


Bloody Sugar!

There is about two teaspoons of glucose in your entire volume of blood at anytime as your body tightly regulates this amount. The pancreas produces insulin to signal muscle cells to take-up the excess glucose that arrives into your blood when food is consumed. Any extra glucose beyond what muscles cells can absorb is next signaled for storage into fat cells. The rate at which the digestive system injects glucose into the blood varies depending on what type of food is consumed. For example, the 8+ teaspoons of sugar in a bottle of soda is absorbed much more rapidly than complex carbs in oatmeal.

The glycemic index a rating that scientist created that indicates what foods create blood glucose spikes relative to table sugar.  There are three macro food groups: Carbohydrates, Fats and Proteins. The digestive system converts all carbohydrates to glucose, so there is not a huge difference between eating sugar, grains, beans or starchy vegetables. It all gets converted to blood glucose, therefore eating too many carbs creates an overabundance of blood glucose.  The glycemic index just indicates foods that create greater insulin spikes.  At the end of the day all carbohydrates become blood sugar and must be chemically processed (metabolized).

Insulin is a growth hormone. When muscles can no longer absorb the glucose, insulin will signal the body to store the remaining excess glucose into fat cells. The fat cells use glucose to grow, thus a person becomes fat!

Note: fructose is is handled differently than glucose. That is another story regarding why eating too much fruit is also bad. Consumption of of fruit should be limited to one small piece a day.

Cancer researchers at Memorial Sloan Kettering have discovered that all cancers have in common gene mutations in glucose uptake.  Cancer now appears to be a signalling problem between excessive glucose in your blood and your organ an gland cells.  When excessive blood glucose is present beyond what muscle and fast cells can store, then insulin signals your glands and organ cells to take-up the glucose. When this happens, to quote the CEO at Memorial Sloan Kettering Cancer Research, “you are off to the races with the formation of a human cancer“.

Counting carbohydrates is critical not only to weight control, it is now recognized as the best way to prevent getting cancer. Over consuming dietary fats does not create an insulin response. Over consuming proteins can create an insulin response that is somewhere in between carbs and fats.

A critical measurement that every person should monitor at home several times a month is one’s fasting blood glucose levels,  This is done after eight hours or more of fasting, typically in the morning before consuming food or water. Testing once a year during a physical exam is not enough data to accurately determine if one has too much glucose in their blood. Today’s guideline is that the normal range should be between 70-100 mg/dL, but some chronic disease researchers are beginning to suggest that the number should be well below 100 and ideally down near 80!


Cancer: A Metabolic Disease

Thomas N. Seyfried
http://www.bc.edu/content/bc/schools/cas/biology/facadmin/seyfried.html

Dominic D’Agostino
http://health.usf.edu/medicine/mpp/profile.html?person_id=24854&Dominic&DAgostino

Even More Links

The Ketogenic Diet Is an Effective Adjuvant to Radiation Therapy for the Treatment of Malignant Glioma
http://www.plosone.org/article/info%3Adoi%2F10.1371%2Fjournal.pone.0036197

What Causes Cancer?
http://www.ketogenic-diet-resource.com/what-causes-cancer.html

Barrow researcher explores innovative cancer treatment
http://www.thebarrow.org/Research/Neuro_Oncology/213930


Cancer: Driven By Sugar & Carbs

Memorial Sloan Kettering President and CEO Craig B. Thompson discusses how cancer cells grow and spread, and explains the link between cell growth and metabolism. He also discusses the link between excess sugar in the diet and cancer, a focus of his laboratory research. He explains that sugar supplies nutrients that tell the cells to divide “and then you’re off to the races of initiating the formation of a human cancer.”

Uncle Pete’s summary notes from these videos:

  1. The most exciting biological event in our lifetime is the sequencing of the human genome. Knowledge about how cancer works is now growing exponentially. We have learned something very important while investigating the human genome over the last five years: you do not inherent cancer!  Only a very small percentage of people have inherited genes that predispose them to cancer. Environmental factors are the number one determination of cancer risk.
  2. Human genome researchers have sequenced the genomes of Sloan Kettering cancer patients and have found the common mutations among all cancers. These mutations are all in the genes that control glucose uptake.
  3. In 2012 the National Cancer Institute announced that a new #1 cause of preventable cancer has emerged: diet and obesity have replaced tobacco as the leading cause of preventable cancer. 
  4. Overeating carbohydrates is the issue. As you become obese you can no longer properly store glucose in muscle and fats cells, so you distribute the overabundance of glucose to all the other cells in your body (note: even skinny people accumulate visceral fat).  This sets in motion the genetic mutations for glucose uptake and you are off to the races in forming cancer.
  5. The type of food you eat matters. Food consists of fats, proteins and carbohydrates. We have spent the last 40 years as a community trying to convince ourselves that fat is the cause of all problems. Every study has failed to do so. Limiting fats does not reduce the incidence of cancer, however if you vary the carbohydrates of the diet the cancer incidence goes up with every percentage increase of the carbohydrates that you overeat. Fats have no effect on cancer, carbohydrates do and proteins are somewhere in the middle.
  6. Armed with this information we have to change the nutritional advice. We are starting to think about how we limit the cancer’s fuel supply (glucose). Hopefully we will take that into the clinic.
  7. NYC mayor Bloomberg has it right by trying to limit the consumption of sugary drinks.

Here are some quotations from Craig B. Thompson and Lewis Cantley, Director of the Cancer Center at Beth Israel in Boston in a New York Times Magazine article published in 2011:

Is Sugar Toxic?

As it was explained to me by Craig Thompson, who has done much of this research and is now president of Memorial Sloan-Kettering Cancer Center in New York, the cells of many human cancers come to depend on insulin to provide the fuel (blood sugar) and materials they need to grow and multiply…. Thompson believes that many pre-cancerous cells would never acquire the mutations that turn them into malignant tumors if they weren’t being driven by insulin to take up more and more blood sugar and metabolize it.

What these researchers call elevated insulin (or insulin-like growth factor) signaling appears to be a necessary step in many human cancers, particularly cancers like breast and colon cancer. Lewis Cantley, director of the Cancer Center at Beth Israel Deaconess Medical Center at Harvard Medical School, says that up to 80 percent of all human cancers are driven by either mutations or environmental factors that work to enhance or mimic the effect of insulin on the incipient tumor cells.

If it’s sugar that causes insulin resistance, they say, then the conclusion is hard to avoid that sugar causes cancer — some cancers, at least — radical as this may seem and despite the fact that this suggestion has rarely if ever been voiced before publicly. For just this reason, neither of these men will eat sugar or high-fructose corn syrup, if they can avoid it. “I have eliminated refined sugar from my diet and eat as little as I possibly can,” Thompson told me, “because I believe ultimately it’s something I can do to decrease my risk of cancer.” Cantley put it this way: “Sugar scares me.”